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Kamidono, “Formation of reactive oxygen species by spermatozoa from asthenospermic patients: Response to treatment with pentoxifylline,” J

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The downstream signaling events increase nuclear translocation of NF-κB, further promoting the production of various proinflammatory and profibrogenic cytokines, such as TNFα, IL-1β, CCL5, and TGFβ, which subsequently induce hepatocyte lipid accumulation and apoptosis and HSC activation